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Goodwill Industries and Am-Vets for when I want to donate stuff (Salvation Army incorporates to much religion on it's downstream offerings). PBS for guilt free radio and television. Wikipedia is the only recipient of any online donation this year.
Lance Armstrong Foundation (my mother chose it when she was dying of pancreatic cancer) and Planned Parenthood for that whole "women should be allowed access to all health care" thing.
Kidney Foundation. Kidney disease killed my mom. Local food banks and homeless missions as it is a direct route to those who need it. A couple of no kill cat shelters.
Planned parenthood usually, this year the money I would give to them went to the red cross and doctors without borders after the tsunami and hurricane, and American Diabetes Association since half my family is diabetic.
I'm a dirt (no, not the fancy store-bought kind, just the stuff that people wipe off their shoes) poor graduate student and I toss them $5 every month - have done so for a couple of years, and plan on upping the amount when I move on financially.
I don't have a particular one I support constantly, unless you consider the homeless dude that sells papers to be a charity. When I have a few extra bucks and I run across something I like that could use some funding, I chuck a bit their way.
I donated to the American Cancer Society this year because my mom has been trying to convince our extended family to donate money we would spend on gifts to a charity instead. So $50 to the ACS gets matched by my work and becomes $100 donated in her name. Serves her right for only asking for metal measuring cups this Christmas.
Since I don't have tons of cash, I find that donating my elbow grease to a particular charity is the best way to give back. Oh yeah, and 5ks are a win-win situation for all parties involved.
The Comic Book Legal Defense Fund (because I publish comics porn) and the new non-profit I'll be starting next year to raise money for more children's books in libraries, in honor of my friend who died from colon cancer this year. She was a month shy of 33, loved books, and changed my life.
Amnesty International
WaterAid
Newspaper appeal collection (this year, Education Action International, Children in Crisis and Practical Action)
Local community (free labour)